An update on molecular cat allergens: Fel d 1 and what else? Chapter 1: Fel d 1, the major cat allergen
نویسندگان
چکیده
منابع مشابه
The major cat allergen, Fel d 1, in diagnosis and therapy.
Sensitization to cat is a common cause of allergic disease all over the world. Symptoms range from mild rhinoconjunctivitis to potentially life-threatening asthmatic exacerbations. In vivo and in vitro diagnostics of cat allergy is currently based on cat dander extract. As allergen extracts from natural sources are heterogeneous in composition, the allergen content may vary. With the introducti...
متن کاملDistribution, aerodynamic characteristics, and removal of the major cat allergen Fel d 1 in British homes.
BACKGROUND Sensitisation to cat allergen (Fel d 1) is an important risk factor for asthma in the UK. A study was undertaken to investigate the distribution of cat allergen in British homes, the aerodynamic characteristics and particle size distribution of airborne Fel d 1, and the method of removing it. METHODS Dust was collected from 50 homes with a cat and from 50 homes without a cat, and a...
متن کاملCat (Fel d 1) and dog (Can f 1) allergen levels in cars, dwellings and schools
Pets are an important source of indoor allergens. The aim of the study was to compare cat and dog allergen levels in cars, schools and homes. The study was carried out in 17 cars, 14 classrooms and 19 dwellings located in the highly industrialized and urbanized region of Poland. Dust and air samples were analyzed for Fel d 1 and Can f 1 using a double monoclonal ELISA assay. The highest amounts...
متن کاملDo hypoallergenic cats exist? -- Determination of major cat allergen Fel d 1 production in normal and hypoallergenic cat breeds
Background and aims Due to the increasing prevalence of cat allergy the demand for so-called hypoallergenic cats and the number of respective breeders is rising. The aim of our study was to examine the hypoallergenicity of these cats, taking the major allergen Fel d 1 as a marker molecule. This molecule is an important asthma inducer and primarily produced in the sebaceous, salivary and anal gl...
متن کاملThe Calcium Goes Meow: Effects of Ions and Glycosylation on Fel d 1, the Major Cat Allergen
The major cat allergen, Fel d 1, is a structurally complex protein with two N-glycosylation sites that may be filled by different glycoforms. In addition, the protein contains three putative Ca2+ binding sites. Since the impact of these Fel d 1 structure modifications on the protein dynamics, physiology and pathology are not well established, the present work employed computational biology tech...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Allergy, Asthma & Clinical Immunology
سال: 2018
ISSN: 1710-1492
DOI: 10.1186/s13223-018-0239-8